DAILY NEWS
Italian minister in trouble
Calls for his resignation abound after stem cell transplant
announcement
Politicians and scientists in Italy are calling for
the resignation of health minister Girolamo Sirchia this week, over a contentious law
on assisted reproduction.
The law, strongly supported by Sirchia, was approved
by the Italian legislature last December. It has been branded
"medieval" by female parliamentarians and gained worldwide
condemnation by scientists.
The legislation bans any testing of embryos for
research and experimental purposes, freezing embryos or embryo
suppression, and forbids preimplantation diagnosis for preventing
genetically transmitted diseases.
It also prohibits donor insemination, limits
fertility treatment to stable, heterosexual couples, and states that
no more than three cells may be fertilized in vitro and that
they must be transferred into the womb simultaneously.
Such tight restrictions, however, have not prevented
a series of "test-tube mix-ups" at fertility centers in recent
months. In one case, two women had to be prescribed the
morning-after pill because each had been inseminated with the wrong
man's sperm.
But Sirchia's real problems began this week, after he
announced the outcome of an innovative stem cell transplant, carried
out at the San Matteo Hospital in Pavia, which cured a five-year-old
boy of thalassemia. The new therapy involved using cells from the
placenta of both of the boy's recently born twin brothers.
While reporting on the "historic outcome" at a press
conference, Sirchia did not mention that the twin brothers were
designer babies, born healthy thanks to preimplantation screening
and assisted reproduction carried out at a fertility center in
Istanbul, Turkey.
"Sirchia wore the peacock feathers for the successful
stem cell transplant, but he did not mention the link with a
procedure which his law bans. He did hide an important part of the
Pavia protocol, fooling around with doctors, patients and, citizens.
He has no choice but resign," said Italian Radical Party secretary
Daniele Capezzone in a statement.
Members of Parliament, including Alessandra
Mussolini, granddaughter of Italy's wartime dictator Benito
Mussolini, also asked for the health minister's resignation.
"I was not informed that the pregnancy was done
through in vitro fertilization with selection of embryos, as
the couple had asked for privacy," Sirchia said in a statement.
Sirchia said the most important aspect in the case
was not the in vitro fertilization. "It has been shown for
the first time that stem cells originating in the placenta and
multiplied in vitro are clinically effective, allowing the
donation of placental blood to be used not only in children, but
also in adults," he said.
"The twin pregnancy realized with in vitro
fertilization and selection of implanted embryos wasn't an
indispensable prerequisite to the scientific results obtained. The
stem cell transplant can be done, with lower probabilities, with
donors born following a natural birth," Sirchia said.
This statement sparked even more controversy. "It was
clear to anybody with some medical knowledge that the stem cell
transplant was linked to preimplantation screening and assisted
reproduction techniques. In other countries, a similar situation
would have immediately determined the minister's resignation,"
fertility expert Carlo Flamigni, Italian pioneer of test-tube baby
technology, told The Scientist.
Meanwhile, another axe is going to fall on the health
minister. The Green Party has requested that Sirchia explain to the
parliament whether there is a conflict of interest regarding his
decision to create a structure in Milan for the conservation of
31,000 frozen "orphan" embryos.
Sirchia allocated 400,000 euros for 2004 to the
transplant transfusion and immunology centre of the Ospedale
Maggiore in Milan–an organization with which the minister has had
very close bounds.
"The center in question opened when Sirchia worked
with transplants, he was head of the department for about 28 years.
The amount of money given to the center is huge. The main cost for
embryo conservation is that one of liquid azote, which costs only 50
cents per litre, " Marco Pannella, the founder of the Italian
Radical Party, said.
In a statement, Sirchia explained that the money
would cover not only the cost of liquid azote, but also "the complex
organization of such a center and embryo transport from centers
across the country to Milan."
Further research, Sirchia added, will involve the
evaluation of cryo-preservation techniques, which would guarantee
the embryo viability.
"Apart from the controversy, one would wonder whether
it is more dignified for a orphan embryo to be used for research
purposes rather than extinguish itself in a freezer," Flamigni
said.